Enhanced retinal degeneration induced by sodium iodate in alphaB‐crystallin knockout mice
نویسندگان
چکیده
منابع مشابه
Protection of Retina by αB Crystallin in Sodium Iodate Induced Retinal Degeneration
Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. The retinal pigment epithelium (RPE) is a critical site of pathology in AMD and αB crystallin expression is increased in RPE and associated drusen in AMD. The purpose of this study was to investigate the role of αB crystallin in sodium iodate (NaIO3)-induced retinal degeneration, a model of AMD in whi...
متن کاملGreen tea catechins are potent anti-oxidants that ameliorate sodium iodate-induced retinal degeneration in rats
Green tea extracts exhibit anti-oxidative and anti-inflammatory actions in different disease conditions. We hypothesized that green tea extract and its catechin constituents ameliorate sodium iodate-induced retinal degeneration in rats by counteracting oxidative stress. In this study, adult Sprague-Dawley rats were intravenously injected with a single dose of sodium iodate. Green tea extract (G...
متن کاملExperimental Pigmentary Degeneration of the Retina by Sodium Iodate.
SEPTOJOD,* which appears to have been introduced in 1920, has been used widely in German-speaking countries for septic conditions on the assumption that nascent iodine is liberated by this preparation in the presence of septic material. It has been especially popular in the treatment of puerperal sepsis. In 1926, Schimmel and Riehm reported two cases of blindness following the intravenous injec...
متن کاملIron-mediated retinal degeneration in haemojuvelin-knockout mice.
Haemochromatosis is a genetic disorder of iron overload resulting from loss-of-function mutations in genes coding for the iron-regulatory proteins HFE (human leucocyte antigen-like protein involved in iron homoeostasis), transferrin receptor 2, ferroportin, hepcidin and HJV (haemojuvelin). Recent studies have established the expression of all of the five genes in the retina, indicating their im...
متن کاملEnhanced Hyperthermia Induced by MDMA in Parkin Knockout Mice
MDMA (3,4-methylenedioxymethamphetamine) is reportedly severely toxic to both dopamine (DA) and serotonin neurons. MDMA significantly reduces the number of DA neurons in the substantia nigra, but not in the nucleus accumbens, indicating that MDMA causes selective destruction of DA neurons in the nigrostriatal pathway, sparing the mesolimbic pathway. Parkinson's disease (PD) is a neurodegenerati...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2010
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.24.1_supplement.38.2